585.729.81 - Cell and Tissue Engineering
Description
Cell and tissue engineering are dynamic and rapidly growing fields within biomedical engineering. This course will examine fundamental biological processes and medical engineering tools essential to regenerative medicine both at the singlecell and the whole-organism levels. Topics include stem cell engineering, cell–matrix and cell–scaffold interactions, cell–cell interactions and tissue morphogenesis, wound healing, and in vitro organogenesis. Prerequisite(s): Knowledge of basic molecular and cellular biology, physiology, and math through ordinary differential equations is required. Students can either take 585.729 OR 580.641/642 unless they have permission from their advisor.
Instructors
Course Structure
The course materials are divided into modules which can be accessed by clicking Course Modules on the course menu. A module will have several sections including the overview, readings, video lectures, discussions, and assignments. You are encouraged to preview all sections of the module before starting. Most modules run for a period of seven (7) days, exceptions are noted in the Course Outline. Module weeks begin on Wednesdays. You should regularly check the Calendar and Announcements for assignment due dates.
Course Topics
- The Challenge - Repairing the Human Body
- Quantum Information Processing and Genetic Engineering
- Cellular Dynamics and High Throughput Biological Data
- Tissue Organization and Dynamics
- Morphogenesis
- Cell Numbers, Growth and Kinetics
- Cell Adhesion and Migration
- Cell and Tissue Mechanics
- Cell Trafficking and Molecular Transport
- Biomaterials and Host Integration
- Stem Cells
- Tissue Engineered Cartilage, Bone, Skin and Nerve
- Artificial Organs
- Final Projects & Semester Wrap-up
Course Goals
Course Learning Outcomes (CLOs)
- Explain the objectives of cellular engineering, what is currently being done, and the challenges in the field.
- Apply fundamental methods to theoretically manipulate genetic material for a specific application.
- Explain the objectives of tissue engineering, what is currently being done and the challenges in the field.
- Apply tissue engineering fundamentals (mechanics, transport, adhesion, and migration) to design solutions to real-world problems.
- Identify medical needs that can be addressed by regenerative medicine approaches.
- Synthesize and collate scientific literature in the fields of cell and tissue engineering.
Textbooks
You do not have to purchase a textbook for this course. The Salzman text is available as a free PDF through the Sheridan Library. The readings for each week will be posted directly into the Blackboard course site through EReserves.
- Saltzman, W.M., (2004). Tissue Engineering. Oxford University Press. ISBN-10: 019514130X ISBN-13: 978-019514130
- Other reference materials will also be included in the course: such as readings from other textbooks, articles, podcasts, and videos. All materials will be posted directly to the course site. No purchases required.
Required Software
Recommended: Microsoft Office Suite
Student Coursework Requirements
The course consist of the following requirements:
1. Weekly Discussions (10% of final grade)
- Discussions are an opportunity to explore the content in different ways.
- For discussion purposes, the class is divided into two groups. Check the 'Syllabus and Course Information' area in the course site to see which discussion group you are assigned to.
- Each discussion is worth 10 points. A rubric for discussions is posted at the top of the Discussions page in the course site.
- Almost all modules include a problem set/assignment. Each assignment is worth 30 points.
- Late submissions will be reduced by one letter grade for each week late (no exceptions without prior coordination with the instructors).
- This course includes a design review project requiring evaluation of an emerging cell/tissue engineered therapy for a medical condition. The project will include short written assignments, a final report, and a short presentation. More detail about the project, including procedures, deliverables, and grading criteria are provided in the project introduction included in module 4.
4. Final Exam (10% 0f final grade)
- The final exam is built directly into Blackboard. You will have two hours to complete it. It will assess your understanding of the course materials as outlined in the course objectives.
Grading Policy
EP uses a +/- grading system (see “Grading System,” Graduate Programs catalog, p. 10).
| Score Range | Letter Grade |
|---|---|
| 100-98 | = A+ |
| 97-94 | = A |
| 93-90 | = A− |
| 89-87 | = B+ |
| 86-83 | = B |
| 82-80 | = B− |
| 79-77 | = C+ |
| 76-73 | = C |
| 72-70 | = C− |
| 69-67 | = D+ |
| 66-63 | = D |
| <63 | = F |
Academic Policies
Deadlines for Adding, Dropping and Withdrawing from Courses
Students may add a course up to one week after the start of the term for that particular course. Students may drop courses according to the drop deadlines outlined in the EP academic calendar (https://ep.jhu.edu/student-services/academic-calendar/). Between the 6th week of the class and prior to the final withdrawal deadline, a student may withdraw from a course with a W on their academic record. A record of the course will remain on the academic record with a W appearing in the grade column to indicate that the student registered and withdrew from the course.
Academic Misconduct Policy
All students are required to read, know, and comply with the Johns Hopkins University Krieger School of Arts and Sciences (KSAS) / Whiting School of Engineering (WSE) Procedures for Handling Allegations of Misconduct by Full-Time and Part-Time Graduate Students.
This policy prohibits academic misconduct, including but not limited to the following: cheating or facilitating cheating; plagiarism; reuse of assignments; unauthorized collaboration; alteration of graded assignments; and unfair competition. Course materials (old assignments, texts, or examinations, etc.) should not be shared unless authorized by the course instructor. Any questions related to this policy should be directed to EP’s academic integrity officer at ep-academic-integrity@jhu.edu.
Students with Disabilities - Accommodations and Accessibility
Johns Hopkins University values diversity and inclusion. We are committed to providing welcoming, equitable, and accessible educational experiences for all students. Students with disabilities (including those with psychological conditions, medical conditions and temporary disabilities) can request accommodations for this course by providing an Accommodation Letter issued by Student Disability Services (SDS). Please request accommodations for this course as early as possible to provide time for effective communication and arrangements.
For further information or to start the process of requesting accommodations, please contact Student Disability Services at Engineering for Professionals, ep-disability-svcs@jhu.edu.
Student Conduct Code
The fundamental purpose of the JHU regulation of student conduct is to promote and to protect the health, safety, welfare, property, and rights of all members of the University community as well as to promote the orderly operation of the University and to safeguard its property and facilities. As members of the University community, students accept certain responsibilities which support the educational mission and create an environment in which all students are afforded the same opportunity to succeed academically.
For a full description of the code please visit the following website: https://studentaffairs.jhu.edu/policies-guidelines/student-code/
Classroom Climate
JHU is committed to creating a classroom environment that values the diversity of experiences and perspectives that all students bring. Everyone has the right to be treated with dignity and respect. Fostering an inclusive climate is important. Research and experience show that students who interact with peers who are different from themselves learn new things and experience tangible educational outcomes. At no time in this learning process should someone be singled out or treated unequally on the basis of any seen or unseen part of their identity.
If you have concerns in this course about harassment, discrimination, or any unequal treatment, or if you seek accommodations or resources, please reach out to the course instructor directly. Reporting will never impact your course grade. You may also share concerns with your program chair, the Assistant Dean for Diversity and Inclusion, or the Office of Institutional Equity. In handling reports, people will protect your privacy as much as possible, but faculty and staff are required to officially report information for some cases (e.g. sexual harassment).
Course Auditing
When a student enrolls in an EP course with “audit” status, the student must reach an understanding with the instructor as to what is required to earn the “audit.” If the student does not meet those expectations, the instructor must notify the EP Registration Team [EP-Registration@exchange.johnshopkins.edu] in order for the student to be retroactively dropped or withdrawn from the course (depending on when the "audit" was requested and in accordance with EP registration deadlines). All lecture content will remain accessible to auditing students, but access to all other course material is left to the discretion of the instructor.